THE CAUSE OF AUTOIMMUNE DISEASES IS REVEALED NOW!
It is understood by autoimmune diseases those originated by the organism itself, which begins to attack healthy cells by mistake. This phenomenon has been studied for decades, leading to continuous discoveries. Specifically, a new discovery was made in this field a few weeks ago by a team of scientists from Boston Children’s Hospital and the School of Medicine at Harvard University (USA).
New research on the cause of autoimmune diseases
This group of scientists has managed to identify, thanks to four years of experimentation with mice, a chain reaction within our body that could be the trigger of autoimmune diseases . “Once the body’s tolerance to its own tissues is lost, the chain reaction is like an out-of-control train. The immune response against the body’s own proteins, or antigens, looks exactly as if the organism were responding to a foreign pathogen , ” explains Michael Carroll, one of the authors of the study.
Much of this project focused on the study of a mouse suffering from lupus , a classic autoimmune disease on which many others are based. “Lupus is known as the great imitator, because the disease can have so many different clinical presentations that it It resembles other common conditions, “says Søren Degn, co-author of the work.
A chain reaction could be the trigger for autoimmune diseases.
Research on the cause of autoimmune diseases focused on B cells , since B lymphocytes have an important role in the regulation of the immune system. These cells produce antibodies and program the immune cells to attack unwanted antigens or foreign substances. However, the experts found a kind of “interruption of cancellation” in the B cells of the mice with which they experimented, which distorts this process and generates autoimmune attacks.
Thanks to all this, the scientists discovered that “over time, the B cells that initially produce the autoantibodies begin to recruit other B cells to produce additional harmful autoantibodies ,” in Degn’s words. So far this has only been observed in mice, but the researchers want to study this technique more thoroughly to analyze how this B cell production of autoantibodies is regulated and accelerated.
The blocking of the germinal centers could suppose a rupture in the vicious circle that the autoimmune diseases create, since it would effectively block the short term memory of the immune system.
This is what Michael Carroll says: “This finding was a surprise. Not only does it tell us that autoreactive B cells are competing within the germ centers to design an autoantibody, but we also saw that the immune response expands to attack other tissues of the body, leading to the epitope extending at the speed of a train out of control “.