PROTEIN RICH DIET HELPS YOU FIGHT ALZHEIMER SYMPTOMS
Scientists from the Gladstone Institute and the University of California, San Francisco, in the United States, report in the Journal of Neuroscience that raising the levels of the life-prolonging protein, Klotho, can protect against learning and memory deficits in a mouse model of Alzheimer’s disease.
Klotho decreases naturally with age, which also leads to a decline in cognitive ability. A previous study of these researchers revealed that having a genetic variant that increases Klotho levels is associated with better cognition in normal, healthy individuals and that experimentally raising Klotho in mice improves learning and memory, but its influence on Cognitive disorders related to aging such as Alzheimer’s.
To test the protective capacity of Klotho, the scientists created a mouse model of Alzheimer’s disease that produced higher levels of this protein throughout the body. In general, Alzheimer model mice have cognitive deficits, abnormal brain activity and premature death, but raising Klotho levels improved these problems. The potentiating effects of protein cognition were powerful enough to counteract the effects of Alzheimer-related toxins, whose levels remained unchanged in this work.
These benefits of Klotho may be due to its effect on a certain type of neurotransmitter receptor in the brain, called NMDA, which is involved in learning and memory. Although Alzheimer’s impairs NMDA receptors, mice with Klotho increase maintain normal receptor levels.